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Skeletal Muscle Weakness Often Occurs In Patients With ME/CFS

Thursday 18 June 2020


From the Journal of Experimental Neurology (via Scientific Archives):


Test tubes

Skeletal Muscle Weakness Often Occurs in Patients with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome ME/CFS

Authors: Yves Jammes, Frédérique Retornaz

Received date: April 16, 2020; Accepted date: May 14, 2020

Citation: Jammes Y, Retornaz F. Skeletal Muscle Weakness Often Occurs in Patients with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS). J Exp Neurol. 2020;1(2): 35-39.

Copyright: © 2020 Jammes Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


• Altered muscle function often occurs in ME/CFS patients.

• Reduced handgrip strength is proportional to lowered physical performance

• Muscle fatigue could result from altered muscle excitability at work

• Reduced central motor command is also documented in relation of encephalomyelitis

• Subgroups of ME/CFS patients without muscle weakness are documented


This commentary complements data reported in Clinical Biomechanics [1] reporting reduced maximal handgrip strength in numerous patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) in proportion to their lowered maximal physical performances.

The causes of muscle weakness in these patients are open to discussion.

Literature data reveal a reduction of central command to skeletal muscles in some ME/CFS patients, related to encephalomyelitis.

Altered muscle membrane excitability, that is “peripheral fatigue”, is also described in relation with an imbalance of the oxidant / anti-oxidant status.

On the other hand, subgroups of chronically fatigued patients with clinical criteria of ME/CFS do not suffer from any muscle weakness.

Thus, clinical data do not sufficiently clarify homogeneous ME/CFS pathology.


Full article…



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