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Low-Dose Naltrexone May Help Some Cases Of Chronic Fatigue Syndrome, Suggests Study

Sunday 2 February 2020


From Medical Dialogues:



Low-Dose Naltrexone May Help Some Cases Of Chronic Fatigue Syndrome, Suggests Study

By Medha
2 February 2020
© 2020 Minerva Medical Treatment Pvt Ltd.

UK: A recent case series published in BMJ Case Reports describes the use of low-dose naltrexone (LDN) for the treatment of chronic fatigue syndrome.

This series of 3 case reports compiled by people with long-term ill-health due to chronic fatigue syndrome shows the range of responses they observed when taking [low-dose naltrexone], from life changing to a reduction in some symptoms only. Treatment doses ranged from 4 to 12 mg.

Chronic fatigue syndrome or myalgic encephalomyelitis is a chronic multisystem disorder characterized by extreme fatigue that is not explained by any underlying medical condition. It doesn't improve with rest and is made worse by exertion.

Naltrexone is used as an off-label treatment in low doses for several chronic immune-modulated disorders in many countries. Although only small-scale clinical trials have been performed, these suggest efficacy in several diseases including Crohn's disease, fibromyalgia and Gulf War Illness. Despite numerous internet reports of response to low-dose naltrexone (LDN), no clinical trials exist in people with chronic fatigue syndrome.


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