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Systems Pathology Of Neuropathic Pain And Fibromyalgia

Monday 25 November 2019


From medical journal the Biological and Pharmaceutical Bulletin:



Systems Pathology of Neuropathic Pain and Fibromyalgia

By Hiroshi Ueda
2019 Volume 42 Issue 11 Pages 1773-1782
© 2019 The Pharmaceutical Society of Japan.


Currently, only a few medicines have been approved for use in the clinical treatment of chronic pain, but they are not fully satisfying due to their side effects.

From the view that radical treatment, rather than simply treating symptoms, is more important in addressing life-long chronic pain, we have been investigating translational research for a mechanism-based medicine to treat pain.

Through the characterization of various types of peripheral and central neuropathic pain in mice, we discovered that lysophosphatidic acid (LPA) plays roles in definitive mechanisms of the development and maintenance of neuropathic pain.

We found LPA1 receptor- and LPA3 receptor-mediated amplification of LPA production could be a key mechanism underlying the initiation and maintenance of this pain.

We have developed stress-induced fibromyalgia models, and have revealed that LPA1 receptor-signaling also plays key roles in the mechanism.

Throughout these studies, we found that LPA plays a key role in pain memory, and that LPA1 receptor- and LPA3 receptor-antagonists could reverse the established pain, and thereby cure the disease source of pain.


Full article…


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