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Altered Microbiome Composition In Individuals With Fibromyalgia

Friday 8 November 2019


From the medical journal Pain:


Woman back pain

Altered microbiome composition in individuals with fibromyalgia

Minerbi, Amira,*; Gonzalez, Emmanuelb,c; Brereton, Nicholas J.B.d; Anjarkouchian, Abrahame; Dewar, Kenc,f; Fitzcharles, Mary-Anna,g; Chevalier, Stéphaniee,h,i; Shir, Yorama

PAIN: November 2019 - Volume 160 - Issue 11 - p 2589-2602
doi: 10.1097/j.pain.0000000000001640
Research Paper

Copyright © 2019
International Association for the Study of Pain.


Fibromyalgia (FM) is a prevalent syndrome, characterised by chronic widespread pain, fatigue, and impaired sleep, that is challenging to diagnose and difficult to treat.

The microbiomes of 77 women with FM and that of 79 control participants were compared using 16S rRNA gene amplification and whole-genome sequencing.

When comparing FM patients with unrelated controls using differential abundance analysis, significant differences were revealed in several bacterial taxa.

Variance in the composition of the microbiomes was explained by FM-related variables more than by any other innate or environmental variable and correlated with clinical indices of FM.

In line with observed alteration in butyrate-metabolising species, targeted serum metabolite analysis verified differences in the serum levels of butyrate and propionate in FM patients.

Using machine-learning algorithms, the microbiome composition alone allowed for the classification of patients and controls (receiver operating characteristic area under the curve 87.8%).

To the best of our knowledge, this is the first demonstration of gut microbiome alteration in nonvisceral pain.

This observation paves the way for further studies, elucidating the pathophysiology of FM, developing diagnostic aids and possibly allowing for new treatment modalities to be explored.


Full article…


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