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Clinical Association Of Vitamin D And Serotonin Levels Among Patients With Fibromyalgia Syndrome

Wednesday 29 May 2019


From Neuropsychiatric Disease and Treatment:



Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome

Authors Amin OA, Abouzeid SM, Ali SA, Amin BA, Alswat KA
Received: 16 December 2018
Accepted for publication: 30 April 2019
Published: 27 May 2019 Volume 2019:15 Pages 1421—1426
Checked for plagiarism: Yes
Review by: Single-blind
Peer reviewers approved by: Dr Colin Mak
Peer reviewer comments: 2
Editor who approved publication: Dr Roger Pinder

Copyright 2019 Informa PLC. All rights reserved.

Omar A Amin,1 Saleh M Abouzeid,2 Siham A Ali,3 Bashir A Amin,4 Khaled A Alswat5

1Department of Orthopedic, Al Noor Specialist Hospital, Makkah, Saudi Arabia;
2Department of Rheumatology, Al Azhar University, Cairo, Egypt;
3Department of Neurology, Banha University, Banha, Egypt;
4Department of Medicine, Taif University, School of Medicine, Taif, Saudi Arabia;
5Department of Medicine and Endocrinology, Taif University School of Medicine, Taif, Saudi Arabia

Objective: Fibromyalgia syndrome (FMS) is a chronic disorder associated with severe pain. According to the National Fibromyalgia Association, the prevalence of FMS is between 3% and 6% in the general population, with about 90% of the patients being women. The primary goal of this study was to evaluate the relationship between vitamin D and serotonin levels and FMS severity.

Methods: Forty participants with fibromyalgia (mean age: 37.8±9.5 years) were included and had their medical history taken, a physical examination, and laboratory testing in the Rheumatology Department at Al-Ameen Hospital in Taif, Saudi Arabia. The revised Fibromyalgia Impact Questionnaire (FIQR) was used to determine the FMS severity.

Results: The results showed that 42.5% of the patients were considered to have mild/moderate fibromyalgia, with the remainder having severe/extreme fibromyalgia. The latter were more likely to have lower serotonin levels. The results showed a significant dose-dependent negative relationship between the serotonin levels and FIQR scores (P=0.002). However, no significant correlations were found between the vitamin D levels and FIQR scores (P=0.112).

Conclusion: The findings of this study show that the improved health of FMS patients is associated with normal serotonin levels.

Keywords: fibromyalgia, vitamin D, serotonin, Saudi Arabia, Taif


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