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ME/CFS SOUTH AUSTRALIA INC

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A Systematic Review Of Enteric Dysbiosis In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Wednesday 26 December 2018

 

From Systematic Reviews:

 

Systematic Reviews
 

A systematic review of enteric dysbiosis in chronic fatigue syndrome/myalgic encephalomyelitis

By 
First Online: 20 December 2018
© 2018 Springer Nature Switzerland AG.

Abstract

Background

Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous constellation of symptoms. The aetiology of this condition remains unknown; however, it has been previously suggested that enteric dysbiosis is implicated in the pathogenesis of CFS/ME. This review examines the evidence currently available for the presence of abnormal microbial ecology in CFS/ME in comparison to healthy controls, with one exception being probiotic-supplemented CFS/ME patients, and whether the composition of the microbiome plays a role in symptom causation.

Methods

EMBASE, Medline (via EBSCOhost), Pubmed and Scopus were systematically searched from 1994 to March 2018. All studies that investigated the gut microbiome composition of CFS/ME patients were initially included prior to the application of specific exclusion criteria. The association between these findings and patient-centred outcomes (fatigue, quality of life, gastrointestinal symptoms, psychological wellbeing) are also reported.

 

Full article…

 


 

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