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Mirtazapine For Fibromyalgia: An Effective Treatment Option?

Thursday 7 June 2018


From MPR:


Mirtazapine appears to be an
effective option for fibromyalgia.

Mirtazapine for Fibromyalgia: An Effective Treatment Option?

June 5, 2018
Copyright © 2018 Haymarket Media, Inc. All Rights Reserved.

The antidepressant mirtazapine appears to be a safe and effective treatment option for patients with fibromyalgia, according to a systematic review published in Rheumatology International.

Mirtazapine is a central alpha-2 antagonist currently FDA-approved for the treatment of major depressive disorder. It is a potent antagonist of 5-HT2 and 5-HT3 serotonin receptors, as well as H1 histamine receptors. "A key difference when compared to other treatment options is that mirtazapine targets many of the symptoms of fibromyalgia with its mechanism of action and simple once daily dosing," explained the authors.

To investigate the role of mirtazapine for fibromyalgia, researchers searched various database and identified 3 randomized, placebo-controlled studies and 1 open-label trial that fit the inclusion criteria. The selected studies lasted 6 to 13 weeks in duration, included mirtazapine doses ranging from 15 to 30mg daily, and evaluated improvements in pain, sleep, and quality of life.


Full article…


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