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Decreased Expression Of TRPM3 And mAChRM3 In The Small Intestine In ME/CFS

Wednesday 6 June 2018


From the International Journal of Clinical Medicine (via Scientific Research):


Test tubes

Decreased Expression of TRPM3 and mAChRM3 in the Small Intestine in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

IJCMVol.9 No.5, May 2018
DOI: 10.4236/ijcm.2018.95040
June 4, 2018
Copyright © 2006-2018 Scientific Research Publishing Inc. All Rights Reserved.

Full-Text HTML XML Download Download as PDF (Size:703KB) PP. 467-480

Author(s) Leave a comment

Sonya Marshall-Gradisnik1,2*, Marshall Fretel1,2, Natalie Eaton1,2, Helene Cabanas1,2, Cassandra Balinas1,2, Vinod Gopalan1, Daniel Petersen2, Rachel Passmore1,2, Kevin Tang2,3, Mazhar Haque4, Alfred Lam1, Donald Staines1,2


1School of Medical Science, Griffith University, Brisbane, Australia.
2The National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Brisbane, Australia.
3Gold Coast University Hospital, Parklands, Australia.
4Mater Hill Gastroenterology, South Brisbane, Australia.


Introduction: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is often associated with gastrointestinal disturbance and inflammatory markers; however, there have been no histological studies performed in the small intestine from CFS/ME patients. The aim of this investigation was to assess the expression of certain inflammatory markers and inflammatory receptors, namely transient receptor potential melastin 3 (TRPM3) ion channels and muscarinic acetylcholine M3 (mAChRM3) receptors, in small intestinal tissues in a case controlled study comprising a CFS/ME patient and a healthy non-fatigued control.

Method: Immunohistochemistry was performed on a small intestinal biopsy from a CFS/ME patient (age = 50; female) with self-reported symptoms of gastrointestinal disturbance and a non-fatigued control (NFC), (age = 28; female). Semi-quantitative analysis of expression was undertaken for interferon-gamma (IFNy), interleukin-1 alpha (IL-1α), tumour necrosis factor-alpha (TNFα), TRPM3 ion channels and mAChRM3 acetylcholine receptors.

Results: There was significantly decreased expression of TRPM3 in the CFS/ME patient (35% ± 9%) and a significant decrease in mAChRM3 in the CFS/ME patient (54% ± 9%). There was no difference in IL-1α between CFS/ME patient and NFC, however; there was an increase in IFNy (13% ± 6%) in the CFS/ME patient compared to NFC. There was a difference observed in TNFα in CFS/ME compared to NFC.

Conclusion: Differences were noted in the expression of specific TRP ion channels and cholinergic receptors in CFS/ME compared with NFC, with CFS/ME demonstrating decreased TRPM3 and mAChRM3. Further, IFNy was increased, and TNFα decreased, in the small intestine of the CFS/ME patient with reported gastrointestinal disturbance.


Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Irritable Bowel, TRPM3, mAChRM3, Small Intestine, Inflammation


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