Society Logo
ME/CFS Australia Ltd
Please click here to donate ME/CFS South Australia Inc

Registered Charity 3104


Mailing address:

PO Box 322,
Modbury North,
South Australia 5092

1300 128 339

Office Hours:
Monday - Friday,
10am - 4pm

ME/CFS South Australia Inc supports the needs of sufferers of Myalgic Encephalomyelitis, Chronic Fatigue Syndrome and related illnesses. We do this by providing services and information to members.


ME/CFS South Australia Inc aims to keep members informed of various research projects, diets, medications, therapies, news items, etc. All communication, both verbal and written, is merely to disseminate information and not to make recommendations or directives.

Unless otherwise stated, the views expressed on this Web site are not necessarily the official views of the Society or its Committee and are not simply an endorsement of products or services.

Become a Member
DOCX Application Form (Word, 198 KB)
Why become a member?

Conflicts Of Interests Affect Fibromyalgia Drug Development

Thursday 25 June 2015


From Fibromyalgia News Today:


Blood tests

Conflicts of Interests Affect Fibromyalgia Drug Development

By Leonor Mateus Ferreira
June 15th, 2015

Over the last few decades there has been a dramatic rise in pharmaceutical industry funding and support of biomedical research. This has led to financial conflicts of interest (FCOIs) between scientific investigators and industry, raising concerns over the possibility of inappropriate influence of industry on biomedical research. Moreover, most studies so far have demonstrated that industry-funded research is linked to an increased probability of pro-industry results.

In a study entitled “Financial conflicts of interest and their association with outcome and quality of fibromyalgia drug therapy randomized controlled trials”, published in International Journal of Rheumatic Diseases, a team of researchers led by Winnie K. Pang, MD, from the University of Southern California-Los Angeles County Medical Center, analyzed the process of drug development and investigation in the field of fibromyalgia research.

The authors concluded that “the majority of FM-RCTs [fibromyalgia drug therapy randomized controlled trials] were industry-sponsored, and had at least one author with an FCOI [financial conflicts of interest]. Reporting of key methodological measures was suboptimal. After adjusting for study sample size, no association of industry funding or author’s FCOI with study outcome was seen.”

This cross-sectional study analyzed data of original, parallel-group, fibromyalgia drug therapy randomized controlled trials, published from 1997 to 2011 in Medline and Cochrane Central Register of Controlled Trials. The main purpose of the analysis was to assess the existence of financial conflicts of interests as well as its relation to the characteristics, results and methodological quality of the trials.

Two independent reviewers evaluated data from 47 RCTs, from which 55,3% were funded by the industry, 17% by non-profit sources, 10,6% had mixed funding, and 17% had unspecified funding. According to the investigators, there is a higher probability for industry funded RCTs to be multicenter and include a larger amount of patients.

The study results also demonstrated that key methodological measures were suboptimal and that both industry and non-profit funded RCTs are similar in their reporting, while 63.8% of the trials had at least one author with disclosed conflicts of interests, including research grants, being an industry sponsor employee, consultancy fee or honorarium and stock ownership.

Despite the current situation of pharmaceutical-sponsored trials and the existence of financial conflicts of interest, the authors believe that “continued surveillance of the potential influence of FCOIs on clinical trial outcomes, and policies to encourage transparent and adequate reporting of clinical trials will help to lessen concerns of industry bias in the study of drug therapies involving FM and other conditions.”

© BioNews Services 2015.
All rights reserved.


The above originally appeared here.


Arrow right

More Fibromyalgia News



blog comments powered by Disqus
Previous Previous Page