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ME/CFS SOUTH AUSTRALIA INC

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Diagnostic Sensitivity Of 2-Day Cardiopulmonary Exercise Testing In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Wednesday 20 March 2019

 

From the Journal of Translational Medicine:

 

Exercise bike
 

Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

By Maximillian J. Nelson, Jonathan D. Buckley, Rebecca L. Thomson, Daniel Clark, Richard Kwiatek, and Kade Davison
Journal of Translational Medicine 201917:80
November 26, 2018
https://doi.org/10.1186/s12967-019-1836-0
Received: 9 January 2019
Accepted: 8 March 2019
Published: 14 March 2019
© The Author(s) 2019

Abstract

Background

There are no known objective biomarkers to assist with the diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A small number of studies have shown that ME/CFS patients exhibit an earlier onset of ventilatory threshold (VT) on the second of two cardiopulmonary exercise tests (CPET) performed on consecutive days. However, cut-off values which could be used to differentiate between ME/CFS patients have not been established.

Methods

16 ME/CFS patients and 10 healthy controls underwent CPET on a cycle-ergometer on 2-consecutive days. Heart rate (HR), ventilation, ratings of perceived exertion (RPE) and work rate (WR) were assessed on both days.

Results

WR at VT decreased from day 1 to day 2 and by a greater magnitude in ME/CFS patients (p < 0.01 group × time interaction). No interaction effects were found for any other parameters. ROC curve analysis of the percentage change in WR at VT revealed decreases of − 6.3% to − 9.8% provided optimal sensitivity and specificity respectively for distinguishing between patients with ME/CFS and controls.

Conclusion

The decrease in WR at VT of 6.3–9.8% on the 2nd day of consecutive-day CPET may represent an objective biomarker that can be used to assist with the diagnosis of ME/CFS.

 

Full article…

 


 

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