Society Logo
ME/CFS Australia Ltd
Please click here to donate ME/CFS Australia (SA) Inc
 
 
Facebook
 
ME/CFS AUSTRALIA (SA) INC

Registered Charity 3104

Email:
sacfs@sacfs.asn.au

Mailing address:
PO Box 322,
Modbury North,
South Australia 5092

Office:
Suite 506,
North Terrace House,
19 North Terrace,
Hackney, SA, 5069


Phone:
1300 128 339

Office Hours:
By appointment

ME/CFS Australia (SA) Inc supports the needs of sufferers of Myalgic Encephalomyelitis, Chronic Fatigue Syndrome and related illnesses. We do this by providing services and information to members.

Disclaimer

ME/CFS Australia (SA) Inc aims to keep members informed of various research projects, diets, medications, therapies, news items, etc. All communication, both verbal and written, is merely to disseminate information and not to make recommendations or directives.

Unless otherwise stated, the views expressed on this Web site are not necessarily the official views of the Society or its Committee and are not simply an endorsement of products or services.

Become a Member
PDF Application Form (PDF, 242KB)
Why become a member?

Decreased Expression Of TRPM3 And mAChRM3 In The Small Intestine In ME/CFS

Wednesday 6 June 2018

 

From the International Journal of Clinical Medicine (via Scientific Research):

 

Test tubes
 

Decreased Expression of TRPM3 and mAChRM3 in the Small Intestine in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

IJCMVol.9 No.5, May 2018
DOI: 10.4236/ijcm.2018.95040
June 4, 2018
Copyright © 2006-2018 Scientific Research Publishing Inc. All Rights Reserved.

Full-Text HTML XML Download Download as PDF (Size:703KB) PP. 467-480

Author(s) Leave a comment

Sonya Marshall-Gradisnik1,2*, Marshall Fretel1,2, Natalie Eaton1,2, Helene Cabanas1,2, Cassandra Balinas1,2, Vinod Gopalan1, Daniel Petersen2, Rachel Passmore1,2, Kevin Tang2,3, Mazhar Haque4, Alfred Lam1, Donald Staines1,2

Affiliation(s)

1School of Medical Science, Griffith University, Brisbane, Australia.
2The National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Brisbane, Australia.
3Gold Coast University Hospital, Parklands, Australia.
4Mater Hill Gastroenterology, South Brisbane, Australia.


ABSTRACT

Introduction: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is often associated with gastrointestinal disturbance and inflammatory markers; however, there have been no histological studies performed in the small intestine from CFS/ME patients. The aim of this investigation was to assess the expression of certain inflammatory markers and inflammatory receptors, namely transient receptor potential melastin 3 (TRPM3) ion channels and muscarinic acetylcholine M3 (mAChRM3) receptors, in small intestinal tissues in a case controlled study comprising a CFS/ME patient and a healthy non-fatigued control.

Method: Immunohistochemistry was performed on a small intestinal biopsy from a CFS/ME patient (age = 50; female) with self-reported symptoms of gastrointestinal disturbance and a non-fatigued control (NFC), (age = 28; female). Semi-quantitative analysis of expression was undertaken for interferon-gamma (IFNy), interleukin-1 alpha (IL-1α), tumour necrosis factor-alpha (TNFα), TRPM3 ion channels and mAChRM3 acetylcholine receptors.

Results: There was significantly decreased expression of TRPM3 in the CFS/ME patient (35% ± 9%) and a significant decrease in mAChRM3 in the CFS/ME patient (54% ± 9%). There was no difference in IL-1α between CFS/ME patient and NFC, however; there was an increase in IFNy (13% ± 6%) in the CFS/ME patient compared to NFC. There was a difference observed in TNFα in CFS/ME compared to NFC.

Conclusion: Differences were noted in the expression of specific TRP ion channels and cholinergic receptors in CFS/ME compared with NFC, with CFS/ME demonstrating decreased TRPM3 and mAChRM3. Further, IFNy was increased, and TNFα decreased, in the small intestine of the CFS/ME patient with reported gastrointestinal disturbance.

KEYWORDS

Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Irritable Bowel, TRPM3, mAChRM3, Small Intestine, Inflammation

 

Full article…

 


 

blog comments powered by Disqus
Previous Previous Page