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ME/CFS AUSTRALIA (SA) INC

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Investigation Of Mast Cell Toll-Like Receptor 3 In ME/CFS

Wednesday 13 December 2017

 

From PubMed:

 

PubMed
 

Investigation of mast cell toll-like receptor 3 in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Systemic Mastocytosis participants using the novel application of autoMACS magnetic separation and flow cytometry.

Balinas C1,2, Nguyen T1,2, Johnston S1,2, Smith P2, Staines D1,2, Marshall-Gradisnik S1,2.
November 17, 2017
Asian Pac J Allergy Immunol. 2017 Dec 10. doi: 10.12932/AP-200517-0086. [Epub ahead of print]

1 School of Medical Science, Griffith University, Gold Coast, QLD, Australia.
2 The National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD Australia.

Abstract

BACKGROUND:

Viral infections and hypersensitivities are commonly reported by Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients. Mast Cells (MC) uniquely mediate type 1 hypersensitivities and resolve viral infections via toll-like receptor 3 (TLR3).

OBJECTIVE:

To characterise and compare mast cell progenitors (MCPs) in CFS/ME participants with a known MC disorder, Systemic mastocytosis (SM), and secondly, to investigate the role of MC TLR3 in CFS/ME participants following Polyinosinic:polycytidylic acid (Poly I:C) stimulation.

 

Full article…

 


 

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