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Chronic Fatigue Syndrome Symptoms Blocked By IM Lidocaine

Saturday 9 September 2017




Roland Staud, MD
Roland Staud, MD

Chronic Fatigue Syndrome Symptoms Blocked By IM Lidocaine

By Marie Benz MD FAAD
August 10, 2017 Interview with:

Roland Staud, M.D.
Professor of Medicine
University of Florida
Gainesville, FL What is the background for this study? What are the main findings?

Response: Fatigue after exertion or sleep loss is normal. However, fatigue at rest is not. Resting fatigue is reported by cancer, heart disease, RA, SLE patients and patients with chronic fatigue syndrome (CFS). CFS has been mostly associated with chronic infections but findings are inconsistent. We hypothesized that chronic fatigue is signaled by sensitized tissue receptors to the CNS where minute amounts of muscle metabolites can activate these receptors (metabo-receptors). Why the receptors are sensitized is unclear. To test our hypothesis we injected CFS patients with lidocaine or normal saline into muscles once. We saw a statistical improvement of overall fatigue (27%) with lidocaine compared to saline.

Conclusion: Chronic fatigue syndrome patients are using metabo-receptors for inappropriately signaling fatigue to the CNS.


Full article…



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