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Gut Bacteria In ME/CFS May Influence Disease Severity

Thursday 27 April 2017


From The Microbe Discovery Project:




By administrator
April 26, 2017
© 2017 The Microbe Discovery Project

“Much like IBS, ME/CFS may involve a breakdown in the bidirectional communication between the brain and the gut mediated by bacteria, their metabolites, and the molecules they influence. By identifying the specific bacteria involved, we are one step closer to more accurate diagnosis and targeted therapies.”
~ Ian Lipkin, director of CII and John Snow Professor of Epidemiology at Columbia’s Mailman School.

Anticipated work from the CII teams’ early investigative research into ME/CFS is starting to be published. The new study in the journal Microbiome from Drs Ian Lipkin and Mady Hornig at Columbia University Center for Infection and Immunity (CII) finds abnormal levels of certain types of bacteria in the gut microbiome of ME/CFS patients. It also found disturbances in bacterial metabolic pathways that, in combination with the changes in bacteria, may influence disease severity.

The CII team collaborated with some of the top clinicians in the field, including Klimas, Peterson, Montoya, Bateman and Levine, to ensure they had rigorously-diagnosed patients. Harvard Professor Tony Komaroff was part of the team too. The open access paper is titled ‘Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome’.

Researchers took fecal and blood samples from 50 patients and 50 healthy controls. They analysed cytokines in the blood, as they did in their original cytokine study and they applied metagenomics to the fecal samples. Metagenomics is a new field that combines remarkable technology for sequencing huge amounts of DNA with a kind of sophisticated genetic detective work to not only identify which bacteria are present, but also which bacterial metabolic pathways are active too. ME/CFS patients differed from controls in both.


Full article…



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