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Evidence of brainstem dysfunction in Fibromyalgia patients
Wednesday 16 October 2013
Evidence of Brainstem Dysfunction in Fibromyalgia Patients
Alterations in excitatory and inhibitory brainstem interneuronal circuits in fibromyalgia: Evidence of brainstem dysfunction.
By M. Kofler and W. Halder
OBJECTIVE: Patients with fibromyalgia syndrome (FMS) perceive stimuli differently and show altered cortical sensory representation maps following peripheral stimulation. Altered sensory gating may play a causal role.
METHODS: Blink reflex, blink reflex excitability recovery, and prepulse inhibition of the blink reflex - representing brainstem excitability - were assessed in 10 female patients with FMS and 26 female healthy controls.
CONCLUSIONS: Blink reflex is normal, whereas blink reflex excitability recovery is enhanced and blink reflex prepulse inhibition is reduced in patients with FMS, suggesting functional changes at the brainstem level in FMS.
SIGNIFICANCE: Reduced blink reflex prepulse inhibition concurs with altered sensory gating in patients with FMS.
Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Source: Clinical Neurophysiology, September 12, 2013. By M. Kofler and W. Halder. Department of Neurology, Hochzirl Hospital, Zirl, Austria.
The above, with comment, originally appeared here.
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