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Epigenetic alterations in women with Fibromyalgia
Friday 11 October 2013
Note: You may read the full text of this article free HERE.
Editor's Comment: “Epigenetics literally means "above" or "on top of" genetics. It refers to external modifications to DNA that turn genes "on" or "off." These modifications do not change the DNA sequence, but instead, they affect how cells "read" genes.” (from LiveScience.com) For more information about epigenetics, including examples, see this article at LiveScience.com.
Epigenetic alterations and an increased frequency of micronuclei in women with fibromyalgia.
By Victoria Menzies, et al.
Fibromyalgia (FM), characterized by chronic widespread pain, fatigue, and cognitive/mood disturbances, leads to reduced workplace productivity and increased healthcare expenses.
To determine if acquired epigenetic/genetic changes are associated with FM, we compared the frequency of spontaneously occurring micronuclei (MN) and genome-wide methylation patterns in women with FM (n = 10) to those seen in comparably aged healthy controls (n = 42 (MN); n = 8 (methylation)).
Results support the need for future research to further examine the potential role of epigenetic and acquired chromosomal alterations as a possible biological mechanism underlying FM.
The above, with comments, originally appeared here.
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