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Study found CoQ10 supplementation improved Fibromyalgia symptoms
Sunday 25 August 2013
Can Coenzyme Q10 Improve Clinical and Molecular Parameters in Fibromyalgia?
By Mario D. Cordero, et al.
Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Its pathophysiological mechanisms are difficult to identify and current drug therapies demonstrate limited effectiveness.
Both mitochondrial dysfunction and coenzyme Q10 (CoQ10) deficiency have been implicated in FM pathophysiology.
We have investigated the effect of CoQ10 supplementation. We carried out a randomized, double-blind, placebo-controlled trial to evaluate clinical and gene expression effects of forty days of CoQ10 supplementation (300 mg/day) on 20 FM patients. This study was registered with controlled-trials.com (ISRCTN 21164124).
These results lead to the hypothesis that CoQ10 have a potential therapeutic effect in FM, and indicate new potential molecular targets for the therapy of this disease. AMPK could be implicated in the pathophysiology of FM.
Source: Antioxidants & Redox Signaling, April 6, 2013. By Mario D. Cordero, Elísabet Alcocer-Gómez, Manuel de Miguel, Ognjen Culic, Angel M. Carrión, José Miguel Alvarez-Suarez, Pedro Bullón, Maurizio Battino, Ana Fernández-Rodríguez, and José Antonio Sánchez-Alcazar. Departamento de Citología e Histología Normal y Patológica, Facultad de Medicina, Universidad de Sevilla , Sevilla, Spain.
The above originally appeared here.
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