Society Logo
ME/CFS Australia Ltd
Please Click Here To Donate ME/CFS Australia (SA) Inc
 
Facebook
 
ME/CFS AUSTRALIA (SA) INC

Registered Charity 698

Email:
sacfs@sacfs.asn.au

Mailing address:
PO Box 28,
Hindmarsh,
South Australia 5007

Office:
Suite 506,
North Terrace House,
19 North Terrace,
Hackney, SA, 5069


Phone:
1300 128 339

Office Hours:
Wednesdays, 11am-3pm
Closed over Christmas
(reopened 1 February 2017)

ME/CFS Australia (SA) Inc supports the needs of sufferers of Myalgic Encephalomyelitis, Chronic Fatigue Syndrome and related illnesses. We do this by providing services and information to members.

Disclaimer

ME/CFS Australia (SA) Inc aims to keep members informed of various research projects, diets, medications, therapies, news items, etc. All communication, both verbal and written, is merely to disseminate information and not to make recommendations or directives.

Unless otherwise stated, the views expressed on this Web site are not necessarily the official views of the Society or its Committee and are not simply an endorsement of products or services.

Become a Member
PDF Application Form (PDF, 277KB)
Why become a member?

High-dose thiamin improves Fibromyalgia symptoms

Tuesday 4 June 2013

 

From ProHealth:

 

ProHealthHigh-Dose Thiamine Improves Fibromyalgia Symptoms

ProHealth.com • May 31, 2013

High-dose thiamine improves the symptoms of fibromyalgia.

By Antonio Costantini, et al.

Abstract:

Living with fibromyalgia means living with chronic pain, fatigue, sleep disorders and other associated key symptoms. To date, pharmacotherapy generally produces modest benefits.

Some observations indicate that the large majority of symptoms of fibromyalgia could be the clinical manifestation of a mild thiamine deficiency due to a dysfunction of the active transport of thiamine from the blood to the mitochondria or to enzymatic abnormalities.

Between June and July 2011, we recruited three female patients affected by fibromyalgia. We proceeded with the study of the patients' history, a physical examination, an evaluation of chronic widespread pain using the Visual Numeric Scale and an evaluation of the fatigue using the Fatigue Severity Scale were also performed. The levels of thiamine and thiamine pyrophosphate in the blood were determined.

After the therapy with high doses of thiamine, in the patients, there was an appreciable improvement of the symptoms.

Source: BMJ Case Reports, May 20, 2013. By Antonio Costantini, Maria Immacolata Pala, Silvia Tundo, and Pietro Matteucci. Department of Neurological Rehabilitation of the Clinic, Villa Immacolata, Viterbo, Italy.

Editor's comment: Although this was a very small study and there was not a healthy control group for comparison, the results are nevertheless noteworthy.

  • Patient 1: 71.3% reduction in fatigue; 80% reduction in pain.

  • Patient 2: 37% reduction in fatigue; 50% reduction in pain.

  • Patient 3: 60.7% reduction in fatigue; 60% reduction in pain.

The therapeutic doses of thiamine ranged from 600 mg to 1800 mg per day. One patient reported improvement at 600 mg. The doses for the other two patients were increased by 300 mg. every three days. Neither reported any improvement until they reached a dosage of 1500 mg. The final therapeutic dose for both was 1800 mg. None of the patients in this study experienced any side effects. The authors did note, however, that in some studies using high-dose thiamine for other illnesses, a few patients experienced side effects like tachycardia and insomnia. Additional and larger studies are needed to confirm these results.

 

The above originally appeared here.

 


Arrow right

More Fibromyalgia News

 


 

blog comments powered by Disqus
Previous Previous Page