ME/CFS South Australia Inc supports the needs of sufferers of Myalgic Encephalomyelitis, Chronic Fatigue Syndrome and related illnesses. We do this by providing services and information to members.
ME/CFS South Australia Inc aims to keep members informed of various research projects, diets, medications, therapies, news items, etc. All communication, both verbal and written, is merely to disseminate information and not to make recommendations or directives.
Unless otherwise stated, the views expressed on this Web site are not necessarily the official views of the Society or its Committee and are not simply an endorsement of products or services.
Evidence that heightened pain perception in CFS linked to oxidative stress
Monday 12 November 2012
By Marvin S Medow, PhD, et al.
[Note: Dr. Medow's research specialties include CFS, orthostatic dysfunction, nutrition, and cellular structure & function. Reactive oxygen species (ROS) are reactive molecules/free radicals – unstable molecules lacking an oxygen atom that are a byproduct of mitochondrial energy production. If not recycled by antioxidants, such as glutathione (which are able to donate a stabilizing oxgen atom to them without themselves becoming unstable), ROS steal oxygen atoms from other molecules in the cell, which in turn are unstabilized, and so on, creating a cell damaging chain reaction. This state is called “oxidative stress.”]
Chronic Fatigue Syndrome (CFS) subjects report increased perception of pain.
To determine the role of ROS in this neurally-mediated response, we evaluated changes in cutaneous blood flow from local heat in 9 CFS subjects (16-22 years) compared to 8 healthy controls (18-26 years).
We heated skin to 42°C and measured local blood flow as a percentage of maximum cutaneous vascular conductance (%CVC(max)).
While CFS subjects had significantly lower baseline flow (8.75+/-0.56 vs. 12.27+/-1.07 (%CVC(max) , CFS vs. control)), there were no differences between groups to local heat.
We then re-measured this with apocynin to inhibit NADPH oxidase, allopurinol to inhibit xanthine oxidase, tempol to inhibit superoxide, and ebselen to reduce H(2)O(2).
Apocynin significantly increased baseline blood flow (before heat, 14.91+/-2.21 vs. 8.75+/-1.66) and the first heat peak (69.33+/-3.36 vs. 59.75+/-2.75).
Allopurinol and ebselen only enhanced the first heat peaks (71.55+/-2.48 vs. 61.72+/-2.01 and 76.55+/-5.21 vs. 58.56+/-3.66, respectively).
Tempol had no effect on local heating.
None of these agents changed the response to local heat in control subjects.
Thus the response to heat may be altered by local levels of ROS, particularly H(2)O(2) [hydrogen peroxide] in CFS subjects, and may be related to their hyperesthesia/ hyperalgesia [abnormally increased sensitivity/pain perception].
Source: Journal of Applied Physiology, Nov 8, 2012. PMID:23139367, by Medow MS, Aggarwal A, Baugham IL, Messer ZR, Stewart JM. New York Medical College, Valhalla, New York, USA. [Email: email@example.com]
The above originally appeared here.
blog comments powered by Disqus