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Coenzyme Q10 in salivary cells correlate with blood cells in Fibromyalgia

Wednesday 29 February 2012

 

From Clinical Biochemistry (via ScienceDirect):

 

ScienceDirectCoenzyme Q10 in salivary cells correlate with blood cells in Fibromyalgia: Improvement in clinical and biochemical parameter after oral treatment

Mario D. Corderoa, b, c, Corresponding author contact information, E-mail the corresponding author, Rocio Santos-Garcíad, David Bermejo-Joverd, Benito Sánchez-Domínguezd, María Reyes Jaramillo-Santosd, Pedro Bullónd

a Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía, ISCIII, Sevilla, Spain
b Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Sevilla, Spain
c Dpto. Citología e Histología Normal y Patológica, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain
d Department of Periodontology, Dental School, University of Sevilla, Spain

Received 12 October 2011. Revised 30 January 2012. Accepted 2 February 2012. Available online 10 February 2012.

http://dx.doi.org/10.1016/j.clinbiochem.2012.02.001, How to Cite or Link Using DOI

Abstract

Objective

We have determined Coenzyme Q10 (CoQ10) levels in salivary cells (SCs) and mononuclear blood cells (BMCs) from Fibromyalgia (FM), and we study the influence of oral CoQ10 supplementation on cells levels and clinical symptoms.

Methods

CoQ10 was determined by high-performance liquid chromatography (HPLC). Ten patients were supplemented daily with 300 mg of CoQ10 during 3 months.

Results

CoQ10 were reduced in both cell models. Oral supplementation showed an improvement in clinical symptoms and restored levels.

Conclusions

Patients with FM showed an important dysfunction in CoQ10 levels and might benefit from oral supplementation.

Abbreviations

  • FM, Fibromyalgia; 
  • CoQ10, Coenzyme Q10; 
  • SCs, Salivary cells; 
  • BMCs, Blood mononuclear cells; 
  • HPLC, high-performance liquid chromatography

Keywords

  • Fibromyalgia; 
  • Coenzyme Q10; 
  • Salivary cells; 
  • Blood mononuclear cells

 

The above originally appeared here.

 


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