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Study demonstrates glutamate dysregulation in Fibromyalgia

Friday 20 January 2012

 

From About.com's Adrienne Dellwo:

 

BrainStudy Demonstrates Glutamate Dysregulation in Fibromyalgia

By Adrienne Dellwo, About.com Guide
January 6, 2012

A new study provides further evidence of high levels of the neurotransmitter glutamate in fibromyalgia and suggests that lowering glutamate levels could help alleviate symptoms.

Researcher say two brain scans - magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) - revealed significantly elevated glutamate in the posterior cingulate cortex compared to healthy controls. Levels were slightly higher than in participants with somatization disorder, which also was a focus of the study.

The posterior cingulate cortex is an area in the center of the brain that deals with awareness, pain and some types of memory retrieval, all of which are involved in fibromyalgia. Previous research has uncovered excess glutamate in the insular cortex.

Glutamate's job is to stimulate neurons, helping you learn new information and form memories. However, when glutamate is too high or remains high for too long, it can over-stimulate cells to the point of dysfunction or even death.

Have you used treatments aimed at regulating glutamate? How effective were they? Leave your comments below!

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The above, with comments, originally appeared here.

 


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