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ME/CFS brain volume anomalies consistent with impaired memory, subtle vision & movement processing changes
Monday 5 December 2011
By Basant K Puri, et al.
[Note: With regard to the suggestion of subtle visual abnormalties, see “UK Study of Visual Function in ME/CFS Announced,” posted Nov 28, 2011.]
Methods: High-resolution structural 3-T cerebral MRI scanning was carried out in 26 CFS patients and 26 age- and gender-matched healthy volunteers. Voxel-wise generalized linear modeling was applied to the processed MR data using permutation-based non-parametric testing, forming clusters at t > 2.3 and testing clusters for significance at p < 0.05, corrected for multiple comparisons across space.
Results: Significant voxels (p < 0.05, corrected for multiple comparisons) depicting reduced grey matter volume in the CFS group were noted in the occipital lobes (right and left occipital poles; left lateral occipital cortex, superior division; and left supracalcrine cortex), the right angular gyrus and the posterior division of the left parahippocampal gyrus.
Significant voxels (p < 0.05, corrected for multiple comparisons) depicting reduced white matter volume in the CFS group were also noted in the left occipital lobe.
These data support the hypothesis that:
They also suggest that subtle abnormalities in visual processing, and discrepancies between intended actions and consequent movements, may occur in CFS.
Source: British Journal of Radiology, Nov 29, 2011. DOI:10.1259/bjr/93889091, by Puri BK, Jakeman PM, Agour M, Gunatilake KDR, Fernando KAC, Gurusinghe AI, Treasaden IH, Waldman AD, Gishen P. Department of Imaging, Hammersmith Hospital, London, UK; Department of Physical Education and Sport Sciences, University of Limerick, Republic of Ireland; University of Hertfordshire, and Care Principles, Rose Lodge, Langley, West Midlands, UK; The Ridge Hill Centre, Dudley, UK; Brooklands Hospital, Birmingham, West Midlands, UK; Broadmoor Hospital, Berkshire, UK; Three Bridges Unit, WLMHT, Middlesex, UK; National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
The above originally appeared here.
The British Journal of Radiology paper appears here:
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