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Webcast of Dr. W. Ian Lipkin's WPI presentation
Sunday 10 July 2011
Dr. W. Ian Lipkin aka the "Virus Hunter," who is currently involved in two CFS studies including one on XMRV, recently spoke at the Whittemore Peterson Institute. Dr. Lipkin has also done viral research on CFS in the past.
The full webcast of his presentation can be found here:
J Neurovirol. 1999 Oct;5(5):495-9. "Absence of evidence of Borna disease virus infection in Swedish patients with Chronic Fatigue Syndrome". Evengård B, Briese T, Lindh G, Lee S, Lipkin WI.
Department of Immunology, Microbiology, Pathology and Infectious Diseases, Clinic for Infectious Diseases, Karolinska Institutet at Huddinge University Hospital.
Chronic Fatigue Syndrome (CFS) is characterized by debilitating fatigue, somatic symptoms and cognitive impairment. An infectious basis has been proposed; candidate agents include enteroviruses, herpesviruses, retroviruses and Borna disease virus (BDV), a novel neurotropic virus associated with neuropsychiatric disorders.
Sera and peripheral blood mononuclear cells (PBMC) from Swedish CFS patients were assayed for evidence of infection using ELISA and Western immunoblot for detection of antibodies to BDV proteins N, P and gp18; and using nested reverse transcriptase polymerase chain reaction (RT-PCR) for detection of BDV N- and P-gene transcripts.
No specific immunoreactivity to BDV proteins was found in sera from 169 patients or 62 controls. No BDV N- or P-gene transcripts were found through RT-PCR analysis of PBMC from 18 patients with severe CFS. These results do not support a role for BDV in pathogenesis of CFS.
The above originally appeared here.
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