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Chronic-fatigue paper called into question

Thursday 2 June 2011

From The Wall Street Journal:


The Wall Street JournalChronic-Fatigue Paper Called Into Question


Editors of the journal Science have asked the co-authors of a 2009 paper that linked chronic fatigue syndrome to a retrovirus called XMRV to voluntarily retract the paper.

But in written response Friday, study co-author Judy A. Mikovits of the Whittemore Peterson Institute for Neuro-Immune Disease said "it is premature to retract our paper." The letter was reviewed by the The Wall Street Journal.

The study raised patients' hopes that if a virus was linked to chronic fatigue syndrome, a treatment might be found. Public-health officials were alarmed by the possibility that supposedly healthy people might unknowingly be infected with a contagious retrovirus. The federal government began an ongoing effort to evaluate whether the nation's blood supply was safe, work that continues.

In the May 26 letter to Dr. Mikovits and her co-authors, also reviewed by the Journal, Science editor-in-chief Bruce Alberts and executive editor Monica Bradford cited concerns about the validity of the findings, saying other scientists hadn't been able to replicate them, among other reasons.

Dr. Mikovits, who confirmed the letters, said she hadn't received a response in return. Dr. Alberts and Ms. Bradford at Science couldn't be reached for comment.

After the 2009 study, other published studies showed that some anti-retrovirals approved for use in HIV might also be effective against XMRV. Some doctors began prescribing anti-retrovirals for chronic fatigue syndrome patients.

The concern about the blood supply led blood banks to bar patients with chronic fatigue syndrome from donating. An advisory committee to the federal Food and Drug Administration recommended last year that the FDA bar people with chronic fatigue syndrome from donating. The FDA hasn't weighed in on the recommendation.

The Centers for Disease Control and Prevention, among other groups, published studies reporting they didn't find XMRV in chronic fatigue syndrome patients. Other papers found that substances used as part of the process to detect XMRV might be contaminated, raising the possibility that this may explain the positive findings in the 2009 Science paper.

In the letter to the study authors, Dr. Alberts and Ms. Bradford suggested the paper be withdrawn "in light of the growing number of research papers from independent investigators who have either failed to replicate your original finding that XMRV is associated with chronic fatigue syndrome and/or who have provided evidence that laboratory reagents are widely contaminated with the virus."

The letter added that two additional papers that "cast further doubt'' on the 2009 paper's findings will be published on June 2 in Science, and that Science will be publishing what it called an editorial expression of concern about the 2009 paper. "At this juncture, Science feels that it would be in the best interest of the scientific community'' for the co-authors to retract the paper, the letter stated.

An editorial expression of concern, while falling short of the journal outright retracting a paper itself, raises a red flag to the scientific community that serious doubts exist about a paper's findings and can make it harder for researchers to obtain funding or publish papers, says R. Grant Steen, a medical communications consultant. He has published papers analyzing 742 English language research papers that were retracted from the PubMed database from 2000-2010.

The 2009 study in question, led by investigators at Whittemore Peterson in Reno, Nev., and including researchers from the National Cancer Institute and the Cleveland Clinic, generated enormous attention among scientists and patients. The researchers reported they found the retrovirus XMRV in a majority of 101 patients with chronic fatigue syndrome, a debilitating condition that involves cognitive dysfunction and severe pain. The authors also found the virus in nearly 4% of 218 healthy people used as controls in the study.

Dr. Mikovits said it was still too early to know the reasons for the differing results in different labs, and that the Institute was looking forward to participating in a major study under way by the NIH and led by Columbia University scientist Ian Lipkin to help clarify the matter.

Write to Amy Dockser Marcus at


The above originally appeared here.

The news of Science's call to retract the paper has appeared elsewhere, with a few editorials:

www 2 June 2011 National Institutes of Health: Origins of XMRV deciphered, undermining claims for a role in human disease
www 2 June 2011 New Scientist: Mouse virus doesn't cause chronic fatigue syndrome
www 2 June 2011 Forbes: Chronic fatigue syndrome: virus hypothesis collapses further
www 1 June 2011 Scientific American: Retrovirus No Longer Thought to Be Cause of Chronic Fatigue Syndrome
www 1 June 2011 The ME Association: Roll out of US media reports on the latest XMRV controversy, 1 June 2011
www 31 May 2011 Retraction Watch: Science asks authors to retract XMRV-chronic fatigue paper; when they refuse, issue Expression of Concern
www 31 May 2011 NPR: Doubts Rise Over Virus As Cause Of Chronic Fatigue Syndrome
www 31 May 2011 BBC News: ‘Concern’ over ME/viral research
www 31 May 2011 The ME Association: Dr Judy Mikovits responds to the ‘Science’ editorial expression of concern, 30 May 2011
www 31 May 2011 The ME Association: Annette Whittemore joins the fray, 31 May 2011
www 31 May 2011 The Wall Street Journal Health Blog: Science Papers ‘Cast Further Doubt’ on XMRV’s Link to Chronic Fatigue Syndrome
www 31 May 2011 Sciencexpress Letter: Editorial Expression of Concern
www 30 May 2011 Phoenix Rising: What Science Giveth Science Try to Taketh Away: Science Journal Asks WPI To Retract XMRV CFS Paper



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