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An etiological model for ME/CFS

Tuesday 5 April 2011

Neuroscience

From the medical journal Neuroscience & Medicine (via ProHealth):

 

An Etiological Model for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome – Source: Neuroscience & Medicine, Mar 2011

ProHealth.com
by Leonard A Jason, et al.
March 29, 2011

[Note: The full text pdf of this article outlining a way that ME/CFS symptoms might develop is available free at http://www.scirp.org/journal/nm/]

Kindling might represent a heuristic model [to be tested] for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Kindling occurs when an organism is exposed repeatedly to an initially sub-threshold stimulus re-sulting in hypersensitivity and spontaneous seizure-like activity.

Among patients with ME/CFS:

  • Chronically repeated low-intensity stimulation due to an infectious illness might cause kindling of the limbic-hypothalamic-pituitary axis.
     
  • Kindling might also occur by high-intensity stimulation (e.g., brain trauma) of the limbic-hypothalamic-pituitary axis.

Once this system is charged or kindled, it can sustain a high level of arousal with little or no external stimulus and eventually this could lead to hypocortisolism [adrenal insufficiency].

Seizure activity may spread to adjacent structures of the limbic-hypothalamic-pituitary axis in the brain, which might be responsible for the varied symptoms that occur among patients with ME/CFS.

In addition, kindling may also be responsible for high levels of oxidative stress [free radicals], which has been found in patients with ME/CFS.

Source: Neuroscience & Medicine, Apr 2011;2, 14-27. DOI:10.4236/nm.2011.21003, by Jason LA, Sorenson M, Porter N, Belkairous N. DePaul University, Center for Community Research, Chicago, Illinois, USA. [Email:ljason@depaul.edu]

 

The above originally appeared here.

 


 

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