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Relationship between gene variant and Fibromyalgia
Wednesday 23 March 2011
U Texas "confirms a relationship" between gene variant & fibromyalgia; may explain differing subgroup responses to meds
by Yangming Xiao, Weijing He, I Jon Russell
Objective: To determine the genotype frequencies of Beta (2)-adrenergic receptor (Beta (2)AR) gene polymorphisms (Gly16Arg, Glu27Gln) in patients with fibromyalgia syndrome (FM) by comparison with unrelated healthy controls.
We sought any clinical association with these polymorphisms and determined whether the polymorphisms would associate with a biologic guanosine protein-coupled stimulator receptor (Gs) dysfunction in FM.
Methods: Study subjects included 97 clinically characterized patients with FM and 59 controls. The Beta (2)AR polymorphisms at codons 16 and 27 were determined using polymerase chain reaction-restriction fragment length polymorphism. The Gs functions of peripheral blood mononuclear cells (PBMC) were tested using isoproterenol (ISO) as the adrenergic Gs ligand and measuring intracellular cyclic adenosine monophosphate (cAMP) levels.
Source: Journal of Rheumatology, Mar 15, 2011. PMID: 21406495, by Xiao Y, He W, Russell IJ. Divisions of Clinical Immunology and Infectious Diseases, Department of Medicine, University of Texas Health Science Center at San Antonio, Texas, USA. [E-mail: firstname.lastname@example.org]
The above, with comments, originally appeared here.
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