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Fibromyalgia: recent study shows elevated levels of eotaxin
Friday 19 June 2009
Yesterday we reported about a study that was published last year on fibromyalgia. In that study, researchers determined that fibromyalgia had a genetic component and that eotaxin and MCP-1 levels were elevated in patients with it and also in members of their families. We also noted that eotaxin expression is upregulated from diesel exhaust and particles. (MedicineWorld.org)
A new study has clarified a new role of eotaxin. The findings of it demonstrate that “eotaxin is also responsible for events when allergic reactions proceed quickly and often become fatal. Eotaxin is a chemokine made by an immune cell that helps the immune system target sites of infection but researchers also have found that it blocks basic “fighter” cells from becoming dendritic cells which results in elevated allergic responses. It is also a ligand for the receptor of MCP-1. The researchers conclude from this study that insights from this work on the unexpected role of eotaxin should provide novel therapeutic opportunities for intervention during diseases like asthma, food allergies and other situations where unchecked allergic responses cause problems.”
Two other studies describe the effects of eotaxin in atopy and nonatopy individuals. “Eotaxin and eotaxin-2 was associated with local eosinophilia. In addition, it was associated with cute wheal and flare response at the site of injection and development of a cutaneous late phase reaction in a proportion of subjects. Thus it was concluded that eotaxin and eotaxin-2 induce eosinophils and other inflammatory mediators that are consistent with mast cell degranulation.” The second study notes that eotaxins are important chemokines for attracting eosinophils and that its activation parallels NF-kappaB which is part of the inflammatory response.
The full article can be found here.
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