Society Logo
ME/CFS Australia Ltd
Please Click Here To Donate ME/CFS Australia (SA) Inc
 
Facebook
 
ME/CFS AUSTRALIA (SA) INC

Registered Charity 698

Email:
sacfs@sacfs.asn.au

Mailing address:
PO Box 28,
Hindmarsh,
South Australia 5007

Office:
Closed while relocating

Phone:
1300 128 339

Office Hours:
Wednesdays, 10am-3pm

ME/CFS Australia (SA) Inc supports the needs of sufferers of Myalgic Encephalomyelitis, Chronic Fatigue Syndrome and related illnesses. We do this by providing services and information to members.

Disclaimer

ME/CFS Australia (SA) Inc aims to keep members informed of the various research projects, diets, medications, therapies etc. All communication, both verbal and written, is merely to disseminate information and not to make recommendations or directives.

Unless otherwise stated, the views expressed on this Web site are not necessarily the official views of the Society or its Committee and are not simply an endorsement of products or services.

Become a Member
PDF Application Form (PDF, 277KB)
Why become a member?
 

Dr Sarah Myhill paper: CFS and mitochondrial dysfunction

Thursday 22 January 2009

DoctorMyhill.co.ukDr Sarah Myhill has published a paper on mitochondrial dysfunction in ME/CFS in the International Journal of Clinical and Experimental Medicine:

PDF

Chronic fatigue syndrome and mitochondrial dysfunction (PDF, 1.54MB)

Here’s the abstract:

Chronic fatigue syndrome and mitochondrial dysfunction

Sarah Myhill, Norman E. Booth, John McLaren-Howard

Sarah Myhill Limited, Llangunllo, Knighton, Powys, Wales LD7 1SL, U.K.; Department of Physics and Mansfield College, University of Oxford, Oxford OX1 3RH, U.K.; Acumen, PO Box 129, Tiverton, Devon EX16 0AJ, U.K.

Received December 3, 2008; accepted January 12, 2009; available online January 15, 2009

Abstract: This study aims to improve the health of patients suffering from chronic fatigue syndrome (CFS) by interventions based on the biochemistry of the illness, specifically the function of mitochondria in producing ATP (adenosine triphosphate), the energy currency for all body functions, and recycling ADP (adenosine diphosphate) to replenish the ATP supply as needed. Patients attending a private medical practice specializing in CFS were diagnosed using the Centers for Disease Control criteria. In consultation with each patient, an integer on the Bell Ability Scale was assigned, and a blood sample was taken for the “ATP profile” test, designed for CFS and other fatigue conditions. Each test produced 5 numerical factors which describe the availability of ATP in neutrophils, the fraction complexed with magnesium, the efficiency of oxidative phosphorylation, and the transfer efficiencies of ADP into the mitochondria and ATP into the cytosol where the energy is used. With the consent of each of 71 patients and 53 normal, healthy controls the 5 factors have been collated and compared with the Bell Ability Scale. The individual numerical factors show that patients have different combinations of biochemical lesions. When the factors are combined, a remarkable correlation is observed between the degree of mitochondrial dysfunction and the severity of illness (P<0.001). Only 1 of the 71 patients overlaps the normal region. The “ATP profile” test is a powerful diagnostic tool and can differentiate patients who have fatigue and other symptoms as a result of energy wastage by stress and psychological factors from those who have insufficient energy due to cellular respiration dysfunction. The individual factors indicate which remedial actions, in the form of dietary supplements, drugs and detoxification, are most likely to be of benefit, and what further tests should be carried out. (IJCEM812001).

Key Words: Chronic fatigue syndrome; myalgic encephalomyelitis; patient care; mitochondria; neutrophils, oxidative phosphorylation.

 


 

blog comments powered by Disqus

Previous Previous Page